Description

2-Chloroadenosine Hemihydrate is a chemically modified nucleoside analog of adenosine, featuring a chlorine substitution at the 2-position of the purine ring. This specific modification is crucial for its role as a potent and selective agonist for adenosine receptors, particularly the A2A subtype, making it a valuable research biochemical. It is primarily utilized by pharmaceutical researchers and life science companies engaged in neuroscience, cardiology, and immunology research, where precise receptor modulation is required for drug discovery and mechanistic studies.

Application

• Pharmacological Research: Used as a standard reference agonist in studies targeting adenosine A2A receptors to investigate signaling pathways and receptor function.
• Drug Discovery & Development: Serves as a key intermediate or reference compound in the synthesis and screening of novel therapeutic agents for neurological and cardiovascular conditions.
• Biochemical Assays: Employed in in vitro and cell-based assays to study adenosine receptor-mediated effects, such as vasodilation, immunosuppression, and neurotransmitter release.
• Academic Research: A fundamental tool in university and institutional labs for basic science research into purinergic signaling and its physiological implications.
• Standards & Calibration: Used to prepare analytical standards for quality control and method development in pharmaceutical analysis using techniques like HPLC and LC-MS.

Basic Information

Product Name	2-Chloroadenosine Hemihydrate
CAS No.	81012-94-4
Molecular Formula	C10H12ClN5O4 • ½H2O
Molecular Weight	298.69 g/mol (Anhydrous basis)
Synonyms	2-Chloroadenosine; 2-Cl-Ado; 2-Chloro-9-β-D-ribofuranosyladenine hemihydrate; 2-Chloroadenosine monohydrate (hemi); Adenosine, 2-chloro-, hemihydrate; 2-CADO; NSC 163039
EINECS	Contact for details

Quality Control

Our 2-Chloroadenosine Hemihydrate is produced under a quality management system and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, suitable for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While typically supplied as a research-grade biochemical, specifications can be aligned with customer requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	2.5% - 4.5% (Theoretical for hemihydrate: ~2.9%)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in DMSO, slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.