Description

γ-(4-(Benzoylphenyl)Methylamido)-7-Methylguanosine-5'-Triphosphate is a chemically modified nucleotide triphosphate analog designed for advanced biochemical research and development. This compound is critical for studying and manipulating nucleic acid processes, offering a unique mechanism of action due to its specific structural modifications. It is primarily utilized by research scientists and process developers in the pharmaceutical, biotechnology, and life sciences sectors for applications in enzymology, molecular biology, and targeted therapeutic discovery.

Application

• Enzymatic Studies & Inhibitor Screening: Serves as a substrate analog or competitive inhibitor for studying the kinetics and mechanisms of polymerases, kinases, and other nucleotide-dependent enzymes.
• Nucleic Acid Labeling & Detection: Used in the development of novel probes for fluorescence-based assays, blotting techniques, and next-generation sequencing platforms.
• Targeted Drug Discovery: Acts as a key intermediate or active component in the synthesis and evaluation of nucleotide-based therapeutics targeting viral replication or specific cellular pathways.
• Structural Biology Research: Employed in X-ray crystallography and NMR studies to elucidate the three-dimensional structure and binding interactions of nucleic acid-protein complexes.
• Diagnostic Assay Development: Incorporated into the design of sensitive and specific diagnostic kits for detecting genetic markers, pathogens, or enzymatic activity.

Basic Information

Product Name	γ-(4-(Benzoylphenyl)Methylamido)-7-Methylguanosine-5'-Triphosphate
CAS No.	80904-71-8
Molecular Formula	C30H31N8O16P3
Molecular Weight	876.56 g/mol
Synonyms	7-Methyl-GTP benzoylphenyl derivative; N-[(4-Benzoylphenyl)methyl]-7-methylguanosine-5'-triphosphoramidate; BzPM-7-Me-GTP; GTP analog, benzophenone-modified; γ-(4-(Benzoylphenyl)methylamido)-7-methyl-GTP; Modified nucleotide triphosphate; Photoactivatable GTP analog; Nucleotide enzyme inhibitor
EINECS	Contact for details

Quality Control

Our production of this high-purity biochemical adheres to stringent quality protocols. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and performance in standard biochemical assays. Our quality system is designed to support GMP-compliant research and development activities.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a non-frost-free freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in DMSO, aqueous buffer (pH ~7)
Biological Activity	Inhibits target polymerase by ≥ 80% at 100 µM (reference assay)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.