Description

(3A,5B,6B,7A,12A)-3,6,7,12-Tetrahydroxy-Cholan-24-Oic Acid is a high-purity, polyhydroxylated bile acid derivative with significant biochemical relevance. This compound serves as a critical intermediate and reference standard in advanced pharmaceutical research and development. It is primarily utilized by research institutions and manufacturers in the life sciences sector for applications in metabolic studies, drug discovery, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel bile acid analogs and steroidal drugs targeting metabolic and liver disorders.
• Biochemical Research: Used as a reference standard and probe in metabolic pathway studies, enzyme inhibition assays, and receptor binding studies.
• Drug Discovery: Serves as a starting material or a critical scaffold in medicinal chemistry programs for developing new therapeutic entities.
• Analytical Standard: Employed as a high-purity calibrant in chromatographic (HPLC, LC-MS) and spectroscopic analyses for quality control and method validation.
• Metabolite Studies: Utilized in research investigating bile acid metabolism, transport, and their role in various physiological and pathological conditions.

Basic Information

Product Name	(3A,5B,6B,7A,12A)-3,6,7,12-Tetrahydroxy-Cholan-24-Oic Acid
CAS No.	80875-93-0
Molecular Formula	C₂₄H₄₀O₆
Molecular Weight	424.57 g/mol
Synonyms	3α,6α,7α,12α-Tetrahydroxy-5β-cholan-24-oic Acid; 3α,6α,7α,12α-Tetrahydroxy-5β-cholanoic Acid; Tetrahydroxycholanic Acid; 3,6,7,12-Tetrahydroxycholanic Acid; 5β-Cholan-24-oic acid, 3α,6α,7α,12α-tetrahydroxy-; Hyocholic Acid (Note: Hyocholic acid typically refers to the 3α,6α,7α-trihydroxy isomer; verify isomer specificity for application).
EINECS	Contact for details

Quality Control

Our (3A,5B,6B,7A,12A)-3,6,7,12-Tetrahydroxy-Cholan-24-Oic Acid is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and stored in a dark environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.