Description

2''-Deoxy-2''-Fluoro-5-Iodocytidine is a modified nucleoside analog of significant interest in pharmaceutical research and development. Its unique structure, incorporating both fluorine and iodine atoms, makes it a valuable building block for creating novel therapeutic agents. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antiviral and anticancer drugs, particularly as a key intermediate in the synthesis of nucleotide prodrugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potent antiviral nucleotide analogs, such as Sofosbuvir and related prodrugs.
• Antiviral Research: Serves as a key scaffold for developing novel therapeutics targeting RNA viruses, including Hepatitis C Virus (HCV).
• Oncology Drug Discovery: Used in the research and development of nucleoside-based chemotherapeutic agents.
• Biochemical Tool: Employed in enzymatic studies and as a substrate analog to investigate polymerase mechanisms.
• Medicinal Chemistry: A versatile building block for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Active Pharmaceutical Ingredient (API) Synthesis: An essential raw material in the multi-step synthesis of complex, high-value APIs.

Basic Information

Product Name	2''-Deoxy-2''-Fluoro-5-Iodocytidine
CAS No.	80791-93-1
Molecular Formula	C9H10FIN3O4
Molecular Weight	385.10 g/mol
Synonyms	5-Iodo-2'-deoxy-2'-fluorocytidine; 2'-Deoxy-2'-fluoro-5-iodocytidine; 2'-F-5-I-Cytidine; 5-I-2'-F-Cytidine; 2'-Fluoro-2'-deoxy-5-iodocytidine; β-2'-Deoxy-2'-fluoro-5-iodocytidine; PSI-6130 Intermediate; RO2433
EINECS	Contact for details

Quality Control

Our 2''-Deoxy-2''-Fluoro-5-Iodocytidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.