Description

3'-Ome-2-Nh2-A is a specialized nucleoside analog building block used in advanced organic synthesis. This compound is critical for researchers and manufacturers developing novel oligonucleotides, antisense therapeutics, and diagnostic probes. It is primarily utilized by the pharmaceutical, biotechnology, and life science research sectors for applications requiring high-purity, custom-modified nucleic acid components. The product is supplied with a Certificate of Analysis to ensure batch-to-batch consistency and reliability for sensitive downstream processes.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA/RNA strands.
• Antisense & siRNA Therapeutics: Used in the research and development of gene-silencing drugs to enhance stability and target specificity.
• Diagnostic Probe Development: Incorporation into fluorescent or quencher-labeled probes for PCR, FISH, and other molecular diagnostic assays.
• Structural Biology Studies: Employed to investigate nucleic acid structure, function, and protein-nucleic acid interactions.
• Apitamer Discovery: Serves as a modified nucleotide in SELEX libraries to generate nuclease-resistant aptamers.
• Chemical Biology Research: A versatile reagent for exploring novel biochemical pathways and creating functionalized biomolecules.

Basic Information

Product Name	3'-Ome-2-Nh2-A
CAS No.	80791-88-4
Molecular Formula	C11H16N6O4
Molecular Weight	296.28 g/mol
Synonyms	2-Amino-3'-O-methyladenosine; 3'-O-Methyl-2-aminoadenosine; 2-NH2-3'-OMe-A; 9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-2-aminopurin-6-one; 2-Aminoadenosine, 3'-O-methyl-; 3'-O-Methyl-2-aminoadenosine; 2-Amino-9-(3-O-methyl-β-D-ribofuranosyl)adenine
EINECS	Contact for details

Quality Control

Every batch of 3'-Ome-2-Nh2-A is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (HPLC), identity (NMR, MS), and moisture content. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. For long-term storage, consider storing at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.