Description

2',3',5'-Tri-o-Acetyl-6-S-Methyl-6-Thio-Guanosine is a key protected nucleoside derivative, essential for advanced oligonucleotide synthesis and pharmaceutical research. This compound serves as a critical building block for the development of modified RNA and DNA analogs, enabling the creation of novel therapeutic agents and diagnostic tools. It is primarily required by research institutions, pharmaceutical companies, and CROs engaged in antisense therapy development, prodrug synthesis, and nucleotide chemistry.

Application

• Pharmaceutical Intermediate: A vital precursor in the synthesis of novel antiviral and anticancer nucleoside prodrugs.
• Oligonucleotide Synthesis: Used as a modified monomer for incorporating thio-modified guanosine residues into antisense oligonucleotides and siRNA.
• Biochemical Research: Employed in studies investigating RNA structure, function, and protein-RNA interactions.
• Prodrug Development: The acetyl protecting groups facilitate controlled release and improved bioavailability of active nucleoside analogs.
• Labeling and Diagnostics: Can be utilized as a starting material for synthesizing fluorescently labeled or radio-labeled nucleotide probes.

Basic Information

Product Name	2',3',5'-Tri-o-Acetyl-6-S-Methyl-6-Thio-Guanosine
CAS No.	80681-58-9
Molecular Formula	C17H21N5O7S
Molecular Weight	439.45 g/mol
Synonyms	6-Thio-2',3',5'-tri-O-acetyl-6-methylmercaptoguanosine; 6-Methylthio-2',3',5'-tri-O-acetylguanosine; 6-S-Methyl-6-thio-2',3',5'-tri-O-acetylguanosine; N2-Acetyl-6-methylmercaptoguanosine triacetate; 6-(Methylthio)-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)guanine; Guanosine, 2',3',5'-triacetate 6-(methylthio) derivative
EINECS	Contact for details

Quality Control

Our 2',3',5'-Tri-o-Acetyl-6-S-Methyl-6-Thio-Guanosine is manufactured under strict quality systems to ensure batch-to-batch consistency for research and production. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.