Description

2'-Deoxy-2'-Fluoroguanylyl-(3'-5')Uridine is a chemically modified dinucleotide, a critical building block in oligonucleotide synthesis. This compound matters for its role in creating therapeutic oligonucleotides with enhanced stability and target-binding affinity, crucial for advancing RNA-based drug discovery and development. It is primarily needed by pharmaceutical R&D teams, CROs/CDMOs, and academic researchers focused on antisense, siRNA, and aptamer technologies.

Application

• Therapeutic Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs).
• RNA Drug Research: Used in the development of modified RNA strands to improve nuclease resistance and pharmacokinetic properties for novel therapeutics.
• Diagnostic Probe Development: Incorporated into fluorescently labeled probes for in situ hybridization (FISH) and other molecular diagnostic assays requiring high specificity.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies to understand RNA-protein interactions and ribonuclease mechanisms.
• Aptamer Engineering: Utilized in SELEX (Systematic Evolution of Ligands by Exponential Enrichment) processes to generate stable, high-affinity nucleic acid aptamers.

Basic Information

Product Name	2'-Deoxy-2'-Fluoroguanylyl-(3'-5')Uridine
CAS No.	80681-27-2
Molecular Formula	C19H23FN8O12P
Molecular Weight	590.41 g/mol
Synonyms	2'-Deoxy-2'-fluoro-GpU; 2'-F-GpU; Guanylyl(3'-5')uridine, 2'-deoxy-2'-fluoro-; 2'-Fluoro-2'-deoxyguanylyl-(3'→5')-uridine; G(2'F)pU; Fluorinated dinucleotide; 2'-F-dinucleotide; 80681-27-2
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-2'-Fluoroguanylyl-(3'-5')Uridine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical research and GMP-grade synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This material is hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere (argon or nitrogen) after each use to maintain stability and prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.