Description

2'-Deoxy-6-Methyl-5-Azacytidine is a chemically modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block and a potent epigenetic modulator, enabling the study and manipulation of DNA methylation processes. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology, epigenetics, and the development of novel therapeutics targeting gene expression.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside-based therapeutics and prodrugs.
• Epigenetic Research: Used as a DNA methyltransferase (DNMT) inhibitor to study gene silencing, cellular differentiation, and reprogramming.
• Oncology Research: Investigated for its potential anti-cancer properties in preclinical studies targeting hematological and solid tumors.
• Biochemical Tool: Employed in enzymatic assays and as a reference standard for analytical method development and validation.
• Life Science Reagent: Utilized in cell culture studies to induce specific phenotypic changes and understand disease mechanisms.

Basic Information

Product Name	2'-Deoxy-6-Methyl-5-Azacytidine
CAS No.	80646-65-7
Molecular Formula	C9H13N3O4
Molecular Weight	227.22 g/mol
Synonyms	6-Methyl-5-aza-2'-deoxycytidine; 5-Aza-2'-deoxy-6-methylcytidine; 6-Methyl-5-aza-dC; 2'-Deoxy-6-methylcytidine, 5-aza-; 4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-methyl-1,3,5-triazin-2(1H)-one
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-6-Methyl-5-Azacytidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.