Description

Tenacigenin B CAS NO 80508-42-5 is a bioactive steroidal sapogenin compound, a key intermediate and reference standard in advanced pharmaceutical research and development. Its significance lies in its role as a crucial building block for the synthesis of novel therapeutic agents and as a validated marker for quality control in botanical extracts. This high-purity compound is essential for research institutions, pharmaceutical companies, and analytical laboratories focused on drug discovery, phytochemistry, and the development of natural product-based medicines.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and purity testing of Marsdenia tenacissima extracts and related formulations.
• Drug Discovery & Medicinal Chemistry: Serves as a key intermediate or lead compound for the semi-synthesis of new chemical entities with potential anticancer, anti-inflammatory, or immunomodulatory activities.
• Phytochemical & Natural Product Research: Employed in academic and industrial research to study the biosynthesis, metabolism, and structure-activity relationships (SAR) of C21 steroidal constituents.
• Analytical Method Development: Utilized to develop and validate analytical methods such as HPLC, LC-MS, and TLC for the quantification of bioactive components in complex botanical matrices.
• Quality Control for Herbal Medicine: Acts as a biomarker to standardize and ensure the batch-to-batch consistency, authenticity, and potency of herbal products containing Marsdenia tenacissima (Tongguanteng).
• Biochemical Research: Applied in pharmacological studies to investigate mechanisms of action, receptor binding, and cellular signaling pathways.

Basic Information

Product Name	Tenacigenin B
CAS No.	80508-42-5
Molecular Formula	C21H32O5
Molecular Weight	364.48 g/mol
Synonyms	Tenacigenin B; (3β,5α,8β,9β,10α,12β,13α,14β,17α)-3,12,14-Trihydroxy-13-methyl-17-[(2R)-5-oxo-2-tetrahydrofuranyl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-18-one; 12β-Hydroxytomentogenin; A constituent of Marsdenia tenacissima; Tongguanteng Genin B
EINECS	Contact for details

Quality Control

Our Tenacigenin B is produced under strict quality management systems to ensure the highest standards of purity and consistency, suitable for research and development applications. Each batch is characterized using advanced analytical techniques including HPLC, MS, and NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and analytical methods is provided with every shipment. We support compliance with relevant pharmacopeial and research guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.