Description

(S)-1-(4-Bromophenyl)-2,2,2-Trifluoroethanol is a high-value, single-enantiomer chiral building block characterized by its bromophenyl and trifluoroethanol functional groups. This compound matters for its critical role in the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its defined stereochemistry and unique fluorine chemistry impart desirable biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, leveraging the fluorine atoms for enhanced efficacy and environmental profile.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and liquid crystals, where the bromine allows for further functionalization.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research into the effects of fluorinated groups on molecular properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific molecule construction.

Basic Information

Product Name	(S)-1-(4-Bromophenyl)-2,2,2-Trifluoroethanol
CAS No.	80418-13-9
Molecular Formula	C8H6BrF3O
Molecular Weight	255.03 g/mol
Synonyms	(S)-4-Bromo-α-(trifluoromethyl)benzyl alcohol; (S)-1-(4-Bromophenyl)-2,2,2-trifluoroethan-1-ol; (S)-α-(Trifluoromethyl)-4-bromobenzyl alcohol; (S)-p-Bromo-α-(trifluoromethyl)benzyl alcohol; (S)-4-Bromo-α,α,α-trifluorotolueneethanol; (S)-1-(p-Bromophenyl)-2,2,2-trifluoroethanol; (S)-Trifluoro(4-bromophenyl)ethanol; (S)-Enantiomer of 1-(4-Bromophenyl)-2,2,2-trifluoroethanol
EINECS	Contact for details

Quality Control

Our (S)-1-(4-Bromophenyl)-2,2,2-Trifluoroethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure compliance with high-purity standards for research and development. Certificates of Analysis (COA) detailing purity, identity, and chiral purity are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive (store away from light) and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.