Description

5-Bromoethynyl-2'-Deoxyuridine is a halogenated nucleoside analog, a key building block in medicinal chemistry and life science research. This compound is valued for its ability to act as a versatile synthetic intermediate, particularly in the development of novel antiviral and anticancer agents. It is primarily utilized by pharmaceutical R&D teams, diagnostic developers, and academic researchers focused on nucleoside chemistry and probe synthesis.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Probe Development: Used to create labeled probes for studying DNA/RNA metabolism and enzyme mechanisms.
• Antiviral Research: Serves as a precursor in the development of compounds targeting viral polymerases.
• Radiopharmaceutical Precursor: Potential intermediate for synthesizing radioiodinated or radiobrominated compounds for diagnostic imaging.
• Academic & Industrial R&D: Fundamental reagent in organic synthesis and medicinal chemistry programs exploring modified nucleosides.
• Cross-Coupling Reactions: The ethynyl group enables Sonogashira and other palladium-catalyzed cross-coupling reactions for creating diverse molecular libraries.

Basic Information

Product Name	5-Bromoethynyl-2'-Deoxyuridine
CAS No.	80384-36-7
Molecular Formula	C11H11BrN2O5
Molecular Weight	331.12 g/mol
Synonyms	5-[(Bromoethynyl)]-2'-deoxyuridine; 5-(2-Bromoethynyl)-2'-deoxyuridine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(2-bromoethynyl)pyrimidine-2,4-dione; 5-Bromoethynyldeoxyuridine; BrEdU; BUdR derivative
EINECS	Contact for details

Quality Control

Our 5-Bromoethynyl-2'-Deoxyuridine is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.