Description

Benzoyl Fluoride, 4-Methyl-3-Nitro- (9Ci) CAS NO 80277-50-5 is a specialized fluorinated aromatic compound that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a reactive benzoyl fluoride group and a nitro substituent, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those requiring fluorinated aromatic scaffolds for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the nitro and fluorine groups contribute to biological activity and environmental persistence profiles.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials with specific optical or electronic properties.
• Organic Synthesis Building Block: Employed in palladium-catalyzed cross-coupling reactions, nucleophilic aromatic substitutions, and other transformations to introduce functionalized benzoyl groups.
• Fluorine Chemistry Studies: A valuable reagent for academic and industrial research exploring new methodologies in fluorination and the reactivity of acyl fluorides.

Basic Information

Item	Detail
Product Name	Benzoyl Fluoride, 4-Methyl-3-Nitro- (9Ci)
CAS No.	80277-50-5
Molecular Formula	C8H6FNO3
Molecular Weight	183.14 g/mol
Synonyms	4-Methyl-3-nitrobenzoyl fluoride; 3-Nitro-4-methylbenzoyl fluoride; 2-Fluorocarbonyl-5-nitrotoluene; 1-Fluoro-4-methyl-3-nitrobenzophenone (misnomer); 4-Methyl-3-nitrobenzoic acid fluoride; 3-Nitro-p-toluoyl fluoride; (4-Methyl-3-nitrophenyl)(fluoro)methanone
EINECS	Contact for details

Quality Control

Our Benzoyl Fluoride, 4-Methyl-3-Nitro- (9Ci) is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the exacting standards required for research and process chemistry. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.