Description

Guanosine 5'-Phospho-2-Methylimidazolide is a chemically activated nucleotide derivative, serving as a crucial building block in synthetic organic and bioorganic chemistry. Its primary value lies in its role as a reactive intermediate for the controlled formation of phosphodiester bonds, enabling the synthesis of oligonucleotides and nucleotide analogs. This compound is essential for researchers and manufacturers in the fields of pharmaceutical development, molecular biology, and diagnostic reagent production, where precise nucleic acid construction is required.

Application

• Oligonucleotide Synthesis: Key activated monomer for the chemical synthesis of RNA and DNA strands in solid-phase and solution-phase methodologies.
• Pharmaceutical Research: Intermediate in the development of nucleotide-based prodrugs, antiviral agents, and other therapeutic nucleic acid analogs.
• Bioconjugation: Used to create labeled nucleotides for diagnostic assays, fluorescence in situ hybridization (FISH), and other probe-based technologies.
• Enzymology Studies: Serves as a substrate analog to study the mechanism of polymerases, ligases, and other nucleic acid-processing enzymes.
• Material Science: Building block for creating functionalized surfaces or polymers with nucleotide motifs for biosensing applications.

Basic Information

Product Name	Guanosine 5'-Phospho-2-Methylimidazolide
CAS No.	80242-42-8
Molecular Formula	C14H18N7O7P
Molecular Weight	451.31 g/mol
Synonyms	2-Methylimidazolide of Guanosine 5'-Monophosphate; GMP-2-Methylimidazolide; Guanosine 5'-(2-Methylimidazolidate) Monophosphate; 5'-GMP-Imidazolide; Guanosine 5'-Monophosphate 2-Methylimidazolide; Guanosine-5'-monophosphoric acid 2-methylimidazolide; Activated GMP; G-Imidazolide
EINECS	Contact for details

Quality Control

Our Guanosine 5'-Phospho-2-Methylimidazolide is produced under stringent conditions to ensure high chemical purity and batch-to-batch consistency, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous internal quality standards, and specifications can be aligned with customer-specific requirements for advanced synthetic work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the container to reach room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.