Description

2'-Deoxycytidylyl-(3--5)-2'-Deoxy-8-(n-Fluoren-2-Ylacetamido)Guanosine is a specialized, chemically modified dinucleotide, a critical building block in advanced oligonucleotide synthesis. This compound matters for its role in creating custom nucleic acid sequences with site-specific modifications, enabling precise control over structure and function. It is essential for researchers and manufacturers in pharmaceutical development, molecular diagnostics, and academic biochemistry who require high-purity, structurally defined intermediates for antisense oligonucleotides, primers, and probes.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): A key phosphoramidite precursor for the automated synthesis of custom DNA/RNA sequences.
• Antisense & siRNA Therapeutics: Used in the research and development of therapeutic oligonucleotides targeting specific genes.
• Molecular Probe Development: Enables the creation of fluorescently labeled or otherwise tagged probes for diagnostic assays and genomic research.
• Structural Biology Studies: Serves as a modified nucleotide for investigating nucleic acid-protein interactions and enzyme mechanisms.
• Synthesis of Modified Aptamers: Facilitates the production of nuclease-resistant or high-affinity aptamers for sensing and therapeutic applications.
• Academic & Industrial R&D: A vital reagent for exploring novel nucleic acid chemistries and developing next-generation biotechnologies.

Basic Information

Product Name	2'-Deoxycytidylyl-(3--5)-2'-Deoxy-8-(n-Fluoren-2-Ylacetamido)Guanosine
CAS No.	80229-05-6
Molecular Formula	C38H41N9O12P
Molecular Weight	822.77 g/mol
Synonyms	d(C-8-FAM-G) Dinucleotide; 2'-Deoxycytidylyl-(3'→5')-2'-deoxy-8-[(9H-fluoren-2-yl)acetamido]guanosine; 8-(2-Fluorenylacetamido)-2'-deoxyguanosine 5'-(3'-→5')-2'-deoxycytidine; Fmoc-dG Modified Dinucleotide; N8-(2-Fluorenylacetamido)-2'-deoxyguanosine-cytidine dinucleotide; Oligonucleotide Synthesis Intermediate; CAS 80229-05-6
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch of 2'-Deoxycytidylyl-(3--5)-2'-Deoxy-8-(n-Fluoren-2-Ylacetamido)Guanosine is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and structural integrity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request. We adhere to GMP principles for handling high-value biochemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light may lead to decomposition. For long-term stability, store under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.