Description

5-Isoxazolecarbonyl Chloride, 3-Ethyl- (9Ci) is a highly reactive and versatile acid chloride derivative of an isoxazole heterocycle, serving as a critical building block for the synthesis of complex amides and esters. Its core value lies in enabling the efficient introduction of the 3-ethylisoxazole-5-carbonyl moiety into target molecules, a key structural motif in medicinal chemistry and advanced material science. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who are developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor for the synthesis of novel drug candidates, particularly in the development of enzyme inhibitors and receptor modulators featuring the isoxazole pharmacophore.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides where the isoxazole ring contributes to biological activity and stability.
• Ligand and Catalyst Development: Employed to create specialized ligands for metal catalysis or functionalized surfaces in material science applications.
• Polymer Modification: Acts as a coupling agent to introduce isoxazole-based functional groups into polymer chains, altering material properties.
• Peptide Mimetics & Bioconjugation: Facilitates the creation of isoxazole-containing peptide analogs and tools for bioconjugation in chemical biology.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	5-Isoxazolecarbonyl Chloride, 3-Ethyl- (9Ci)
CAS No.	80173-67-7
Molecular Formula	C6H6ClNO2
Molecular Weight	159.57 g/mol
Synonyms	3-Ethyl-5-isoxazolecarbonyl chloride; 3-Ethylisoxazole-5-carbonyl chloride; 3-Ethyl-1,2-oxazole-5-carbonyl chloride; 5-Carboxy-3-ethylisoxazole chloride; 3-Ethyl-5-isoxazolyl carbonyl chloride; 3-Ethyl-5-isoxazole carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 5-Isoxazolecarbonyl Chloride, 3-Ethyl- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and highly volatile nature, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C). Keep away from strong acids, bases, and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.