Description

5-(2-Cyanovinyl)-2'-Deoxyuridine is a modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a key synthetic intermediate and a versatile building block for the creation of novel antiviral and anticancer agents. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in nucleoside chemistry, medicinal chemistry, and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Antiviral Drug Research: A critical precursor in the synthesis of nucleoside analogs targeting viral polymerases, particularly for herpesviruses and other DNA viruses.
• Anticancer Agent Development: Used as a building block for creating prodrugs and novel chemotherapeutic agents designed to inhibit cancer cell proliferation.
• Medicinal Chemistry & Lead Optimization: Serves as a versatile scaffold for structure-activity relationship (SAR) studies to improve potency and selectivity of therapeutic candidates.
• Biochemical Research: Employed in studies investigating enzyme mechanisms, such as thymidine kinase, and DNA synthesis pathways.
• Synthesis of Labeled Compounds: A starting material for the preparation of radiolabeled or fluorescently tagged nucleosides for diagnostic and tracking applications.
• Academic Research: Used in university and institutional labs for fundamental studies in organic synthesis and bioorganic chemistry.

Basic Information

Product Name	5-(2-Cyanovinyl)-2'-Deoxyuridine
CAS No.	80173-35-9
Molecular Formula	C₁₂H₁₃N₃O₅
Molecular Weight	279.25 g/mol
Synonyms	5-[(1E)-2-Cyanoethenyl]-2'-deoxyuridine; (E)-5-(2-Cyanovinyl)-2'-deoxyuridine; 5-CVDU; NSC 614846; 2'-Deoxy-5-(2-cyanovinyl)uridine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-[(E)-2-cyanovinyl]pyrimidine-2,4-dione
EINECS	Contact for details

Quality Control

Our 5-(2-Cyanovinyl)-2'-Deoxyuridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support development projects requiring material for pre-clinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.