Description

3-(4-Fluoro-Phenyl)-Prop-2-Yn-1-Ol is a versatile fluorinated alkyne building block, also known by its CAS number 80151-28-6. This compound is valued for its unique molecular structure, which combines a terminal alkyne group with a fluorinated aromatic ring, making it a critical intermediate in advanced organic synthesis. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic or alkyne functional groups.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom can enhance biological activity and stability.
• Material Science Research: Serves as a monomer or precursor in the synthesis of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Click Chemistry: An ideal substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, a cornerstone of bioconjugation and polymer functionalization.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, Sonogashira couplings, and other catalytic transformations to create complex molecular architectures.

Basic Information

Product Name	3-(4-Fluoro-Phenyl)-Prop-2-Yn-1-Ol
CAS No.	80151-28-6
Molecular Formula	C9H7FO
Molecular Weight	150.15 g/mol
Synonyms	4-Fluorophenyl propargyl alcohol; 1-(4-Fluorophenyl)-2-propyn-1-ol; 3-(4-Fluorophenyl)-2-propyn-1-ol; 4-Fluorobenzene propargyl alcohol; 4-Fluorophenylpropynol; 4-Fluorophenyl-2-propyn-1-ol; 4-Fluorobenzyl propargyl alcohol; 80151-28-6
EINECS	Contact for details

Quality Control

Our 3-(4-Fluoro-Phenyl)-Prop-2-Yn-1-Ol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with data from techniques including HPLC, GC, NMR, and IR spectroscopy. Our quality commitment ensures the material meets the high standards required for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.