Description

(R)-3-Chloro-2-Methylpropionyl Chloride is a high-purity chiral building block and a key intermediate in organic synthesis. This compound is valued for its role in introducing the (R)-3-chloro-2-methylpropionyl moiety into target molecules, enabling the production of enantiomerically pure pharmaceuticals and agrochemicals. It is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality chiral intermediates.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of cardiovascular and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and pesticides, where the specific stereochemistry is crucial for bioactivity.
• Asymmetric Synthesis: Serves as a versatile electrophile in asymmetric C-C and C-N bond-forming reactions to construct complex chiral molecules.
• Peptide Mimetics & Modifications: Employed for the acylation of amino groups to create peptide analogs and modify biomolecules.
• Ligand & Catalyst Development: Acts as a precursor for synthesizing chiral ligands and organocatalysts used in stereoselective transformations.
• Fine Chemical Production: Integral in the multi-step synthesis of specialty chemicals, flavors, and fragrances requiring high stereochemical purity.

Basic Information

Product Name	(R)-3-Chloro-2-Methylpropionyl Chloride
CAS No.	80141-51-1
Molecular Formula	C4H6Cl2O
Molecular Weight	141.00 g/mol
Synonyms	(R)-3-Chloro-2-methylpropanoyl chloride; (R)-3-Chloro-2-methylpropanoic acid chloride; (R)-2-Methyl-3-chloropropionyl chloride; (R)-β-Chloro-α-methylpropionyl chloride; (R)-1-Chloro-2-methyl-3-oxopropane; (R)-3-Chloro-2-methyl-1-oxopropane; (R)-Methyl 3-chloropropionyl chloride (stereospecific)
EINECS	Contact for details

Quality Control

Our (R)-3-Chloro-2-Methylpropionyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for synthetic intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed and handled under dry conditions to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (Karl Fischer)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.