Description

5-(2-Fluorovinyl)-2'-Deoxyuridine is a fluorinated nucleoside analog, a key intermediate in the synthesis of advanced antiviral and anticancer agents. Its unique structure, incorporating a fluorovinyl group, is critical for developing targeted prodrugs and diagnostic probes with enhanced metabolic stability and specificity. This high-purity building block is essential for pharmaceutical R&D and fine chemical synthesis, particularly for researchers developing next-generation therapeutics against viral infections and oncology targets.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel antiviral drugs, particularly those targeting herpesviruses and other DNA viruses.
• Anticancer Prodrug Development: Used in research to create targeted chemotherapeutic agents that are activated specifically within tumor cells.
• Biochemical Research: Serves as a tool compound for studying enzyme mechanisms, particularly thymidine kinase, and for probing nucleotide metabolism pathways.
• Diagnostic Agent Synthesis: Employed in the development of Positron Emission Tomography (PET) tracers and other molecular imaging probes labeled with fluorine-18.
• Nucleoside Chemistry: A valuable building block for medicinal chemists exploring structure-activity relationships (SAR) in modified nucleosides.

Basic Information

Product Name	5-(2-Fluorovinyl)-2'-Deoxyuridine
CAS No.	80015-51-6
Molecular Formula	C11H13FN2O5
Molecular Weight	272.23 g/mol
Synonyms	5-(2-Fluorovinyl)-2'-deoxyuridine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(2-fluorovinyl)pyrimidine-2,4-dione; 2'-Deoxy-5-(2-fluorovinyl)uridine; FVdU; (E)-5-(2-Fluorovinyl)-2'-deoxyuridine; 5-(2-Fluoroethenyl)-2'-deoxyuridine
EINECS	Contact for details

Quality Control

Our 5-(2-Fluorovinyl)-2'-Deoxyuridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, with analytical methods including HPLC, NMR, and MS. We adhere to cGMP principles for the production of advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.