Description

5'-Chloro-5'-Deoxyadenosine is a halogenated nucleoside derivative, a crucial building block in synthetic organic chemistry and pharmaceutical research. This modified adenosine analog serves as a key intermediate for the development of novel antiviral and anticancer agents, enabling targeted molecular modifications. It is primarily utilized by research institutions and pharmaceutical companies engaged in nucleoside chemistry, medicinal chemistry, and the synthesis of nucleotide-based therapeutics.

Application

• Pharmaceutical Intermediate: A vital precursor in the synthesis of novel nucleoside-based antiviral and anticancer drugs.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to develop new therapeutic candidates.
• Biochemical Probe Development: Employed in creating labeled or modified nucleotides for studying enzyme mechanisms and biological pathways.
• Antisense Oligonucleotide Synthesis: Serves as a modified monomer for the production of oligonucleotides with enhanced stability or specific activity.
• Academic & Industrial R&D: Fundamental research tool in universities and corporate labs focusing on nucleic acid chemistry and drug discovery.

Basic Information

Product Name	5'-Chloro-5'-Deoxyadenosine
CAS No.	892-48-8
Molecular Formula	C10H12ClN5O3
Molecular Weight	285.69 g/mol
Synonyms	5'-Chloro-5'-deoxyadenosine; 9-β-D-Ribofuranosyl-6-chloro-9H-purin-2-amine; 6-Amino-5'-chloro-5'-deoxy-9-β-D-ribofuranosylpurine; 5'-Chloro-2'-deoxyadenosine (common misnomer, verify structure); 5'-Cl-5'-dA; Adenosine, 5'-chloro-5'-deoxy-; 6-Amino-5'-chloro-5'-deoxyadenosine; 5'-Chloro-5'-deoxy-adenosine
EINECS	Contact for details

Quality Control

Our 5'-Chloro-5'-Deoxyadenosine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.