Description

L-(-)-α-Methyldopa (Hydrochloride) is a high-purity, enantiomerically pure pharmaceutical intermediate and active pharmaceutical ingredient (API). This compound is critical for the synthesis of specific antihypertensive medications, offering a targeted mechanism of action. It is primarily required by pharmaceutical manufacturers, research institutions, and fine chemical producers engaged in cardiovascular drug development and production.

Application

• Pharmaceutical API: Primary use as the active ingredient in antihypertensive medications.
• Chemical Synthesis: Key chiral building block for the synthesis of more complex drug molecules.
• Biochemical Research: Used in pharmacological studies to investigate adrenergic mechanisms and blood pressure regulation.
• Reference Standard: Serves as a high-purity standard for analytical testing and quality control in pharmaceutical labs.
• Process Development: Utilized in R&D for optimizing manufacturing routes for L-Dopa derivatives.

Basic Information

Product Name	L-(-)-α-Methyldopa (Hydrochloride)
CAS No.	884-39-9
Molecular Formula	C10H14ClNO4
Molecular Weight	247.68 g/mol
Synonyms	L-α-Methyldopa Hydrochloride; (-)-α-Methyldopa Hydrochloride; Levodopa Methyl Ester Hydrochloride; (S)-3-(3,4-Dihydroxyphenyl)-2-methylalanine Hydrochloride; MK-351 Hydrochloride; Aldometil; Medomet; Methyldopa Hydrochloride (L-form); L-3-(3,4-Dihydroxyphenyl)-2-methylalanine Hydrochloride
EINECS	212-928-9

Quality Control

Our L-(-)-α-Methyldopa (Hydrochloride) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and compliance with relevant guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Optical Rotation [α]	-25° to -30° (c=1 in 1N HCl)
Chiral Purity (Enantiomeric Excess)	≥99.0%
Loss on Drying	≤1.0%
Residue on Ignition (Sulfated Ash)	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.