Description

3-o-Benzyl Estrone is a key synthetic steroid intermediate, specifically a benzyl-protected derivative of estrone. This compound is valued for its role in facilitating complex organic syntheses by providing a protected hydroxyl group, which is crucial for achieving high selectivity and yield in subsequent reaction steps. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel steroid-based therapeutics and advanced chemical entities.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of advanced steroid drugs and hormone analogs.
• Organic Synthesis Research: Used in academic and industrial R&D for studying steroid chemistry and developing new synthetic methodologies.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Process Chemistry: Employed in scale-up and process optimization for the production of active pharmaceutical ingredients (APIs).
• Biochemical Research: Used in studies investigating estrogen receptor interactions and metabolic pathways.

Basic Information

Product Name	3-o-Benzyl Estrone
CAS No.	858-98-0
Molecular Formula	C26H30O2
Molecular Weight	374.52 g/mol
Synonyms	3-Benzyloxyestra-1,3,5(10)-trien-17-one; Estrone 3-benzyl ether; 3-Benzyloxy-17-oxoestra-1,3,5(10)-triene; 3-O-Benzylestrone; 3-Benzylestrone; Benzyl Estrone Ether; 3-Benzyloxyestra-1,3,5(10)-trien-17-one; 3-Benzyloxy-17-ketoestra-1,3,5(10)-triene
EINECS	Contact for details

Quality Control

Our 3-o-Benzyl Estrone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.