Description

2'-Deoxy-5-(Methylamino)Uridine is a modified nucleoside analog of significant interest in advanced biochemical research and development. This compound serves as a critical building block and research tool in the synthesis of oligonucleotides and the study of nucleic acid interactions. It is primarily utilized by pharmaceutical R&D teams and academic laboratories focused on oncology, virology, and molecular biology. The product, identified by CAS NO 840-50-6, is supplied to meet the stringent purity requirements of these high-value applications.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of novel nucleoside-based therapeutics and prodrugs.
• Antiviral & Anticancer Agent Studies: Used in biochemical assays to investigate mechanisms of action and structure-activity relationships (SAR).
• Oligonucleotide Synthesis: Serves as a modified monomer for creating labeled probes or functionalized nucleic acid strands for diagnostic and research purposes.
• Enzymology Studies: Employed as a substrate or inhibitor to study the activity of kinases, nucleoside phosphorylases, and other enzymes involved in nucleotide metabolism.
• Biochemical Reference Standard: Used for method development and calibration in analytical techniques like HPLC and LC-MS within quality control laboratories.

Basic Information

Product Name	2'-Deoxy-5-(Methylamino)Uridine
CAS No.	840-50-6
Molecular Formula	C10H15N3O5
Molecular Weight	257.24 g/mol
Synonyms	5-(Methylamino)-2'-deoxyuridine; 5-(Methylamino)deoxyuridine; 5-Methylaminodeoxyuridine; dMAdU; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(methylamino)pyrimidine-2,4(1H,3H)-dione; 2'-Deoxy-5-(methylamino)uridine; 5-(N-Methylamino)-2'-deoxyuridine
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-5-(Methylamino)Uridine is produced under a strict quality management system to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical methods including HPLC, NMR, and mass spectrometry. We adhere to relevant industry guidelines to support our customers' compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.