Description

6-Mercaptopurine Ribonucleoside 5'-Diphosphate is a biologically significant nucleotide analog and a key metabolite of the chemotherapeutic agent 6-mercaptopurine. This compound matters as a critical biochemical tool for studying purine metabolism, enzyme kinetics, and the mechanisms of immunosuppressive and anticancer therapies. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for drug discovery, biochemical research, and as a reference standard.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to purine and nucleotide metabolism.
• Pharmaceutical Development: Serves as a key reference standard and intermediate in the research and quality control of thiopurine-based drugs.
• Cancer Research: Employed in studies investigating the mechanism of action, resistance, and metabolism of antimetabolite chemotherapeutic agents.
• Immunology Studies: Applied in research on immunosuppressive pathways and T-cell function modulation.
• Diagnostic Reagent Manufacturing: Potential use as a component in enzymatic assay kits for clinical diagnostics.
• Academic Research: A vital reagent for universities and research institutes focusing on molecular biology, pharmacology, and medicinal chemistry.

Basic Information

Product Name	6-Mercaptopurine Ribonucleoside 5'-Diphosphate
CAS No.	805-63-0
Molecular Formula	C10H15N4O10P2S
Molecular Weight	445.25 g/mol
Synonyms	6-Thioinosine 5'-diphosphate; 6-Thio-IMP; 6-Thioinosine monophosphate (discontinued name for diphosphate form); 6-MP ribonucleoside diphosphate; Thioinosine diphosphate; NSC 4911; 6-Thioinosinic acid (diphosphate); 6-Mercaptopurine-9-riboside 5'-diphosphate
EINECS	Contact for details

Quality Control

Our 6-Mercaptopurine Ribonucleoside 5'-Diphosphate is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (UV, NMR), to ensure it meets high-purity research-grade specifications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, consider desiccation and storage under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (UV)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, alkaline solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.