Description

[[5-(4-Amino-2-Oxo-Pyrimidin-1-Yl)-3-Hydroxy-Oxolan-2-Yl]Methoxy-Hydroxy-Phosphoryl]Oxyphosphonic Acid is a high-purity, complex nucleotide analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block and intermediate for the synthesis of novel antiviral and anticancer therapeutics. It is primarily required by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleoside chemistry and prodrug development.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of next-generation antiviral and anticancer nucleotide prodrugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to DNA/RNA synthesis and repair mechanisms.
• Prodrug Development: Serves as a masked phosphate moiety in the design of bioreversible prodrugs to enhance cellular uptake and bioavailability.
• Antiviral Agent Synthesis: Critical building block for the development of nucleotide analogs targeting viral polymerases.
• Labeled Compound Synthesis: Intermediate for the preparation of isotopically labeled (e.g., 13C, 15N, 32P) compounds for metabolic and pharmacokinetic studies.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to optimize the potency and selectivity of nucleoside-based drug candidates.

Basic Information

Product Name	[[5-(4-Amino-2-Oxo-Pyrimidin-1-Yl)-3-Hydroxy-Oxolan-2-Yl]Methoxy-Hydroxy-Phosphoryl]Oxyphosphonic Acid
CAS No.	800-73-7
Molecular Formula	C10H17N3O12P2
Molecular Weight	433.20 g/mol
Synonyms	1-(2-Deoxy-β-D-erythro-pentofuranosyl)cytosine 5'-(trihydrogen diphosphate); dCMP; Deoxycytidine 5'-monophosphate; Deoxycytidylic acid; 2'-Deoxycytidine 5'-phosphate; Cytosine deoxyribonucleotide; 5'-dCMP; NSC 20264
EINECS	Contact for details

Quality Control

Our [[5-(4-Amino-2-Oxo-Pyrimidin-1-Yl)-3-Hydroxy-Oxolan-2-Yl]Methoxy-Hydroxy-Phosphoryl]Oxyphosphonic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.