Description

Linifanib (ABT-869) is a potent, orally bioavailable, multi-targeted receptor tyrosine kinase inhibitor. This compound is a critical research tool for investigating signaling pathways involved in angiogenesis and tumor proliferation. It is primarily utilized by pharmaceutical R&D teams and academic researchers in the fields of oncology and medicinal chemistry for preclinical studies and drug discovery programs.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel anticancer therapeutics.
• Preclinical Oncology Studies: Used in in vitro and in vivo models to study the efficacy of multi-kinase inhibition on various solid tumors and hematologic malignancies.
• Biochemical Assay Development: Employed as a potent inhibitor to validate assays targeting vascular endothelial growth factor receptors (VEGFR) and platelet-derived growth factor receptors (PDGFR).
• Mechanism of Action (MoA) Research: A vital tool for elucidating the role of specific tyrosine kinases in cellular signaling cascades related to cancer progression.
• Medicinal Chemistry & SAR Studies: Used as a core structure or benchmark compound for structure-activity relationship (SAR) analysis to design new kinase inhibitor analogs.

Basic Information

Product Name	Linifanib (ABT-869)
CAS No.	796967-16-3
Molecular Formula	C₂₁H₁₈FN₅O
Molecular Weight	375.40 g/mol
Synonyms	ABT-869; ABT 869; N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea; Linifanib; 4-[4-[[(2-Fluoro-5-methylphenyl)amino]carbonyl]amino]phenyl]-1H-indazol-3-amine
EINECS	Contact for details

Quality Control

Our Linifanib (ABT-869) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.