Description

Esomeprazole Zn CAS NO 793668-08-3 is the zinc salt of the proton pump inhibitor esomeprazole, offering enhanced stability and handling properties. This compound is a critical active pharmaceutical ingredient (API) intermediate used in the development of advanced gastrointestinal therapeutics. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the formulation of solid dosage forms for the treatment of acid-related disorders.

Application

• Pharmaceutical API Synthesis: Key intermediate in the production of esomeprazole magnesium trihydrate, the active ingredient in leading anti-ulcer medications.
• Solid Dosage Form Development: Used in the research and manufacturing of enteric-coated tablets and capsules due to its stability profile.
• Gastrointestinal Drug Formulations: Essential for developing treatments for gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development and quality control in pharmaceutical labs.
• Process Chemistry & Scale-up: Employed in process optimization and pilot-scale synthesis for commercial pharmaceutical production.
• Novel Drug Delivery Systems: Investigated for use in controlled-release and combination drug delivery platforms.

Basic Information

Item	Detail
Product Name	Esomeprazole Zn
CAS No.	793668-08-3
Molecular Formula	C34H36MgN6O6S2 • Zn (Coordination complex)
Molecular Weight	Contact for details
Synonyms	Esomeprazole Zinc Salt; (S)-Omeprazole Zinc Salt; Esomeprazole Zinc Complex; Zinc Esomeprazole; 5-Methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole Zinc Salt; Nexium® Intermediate; Perprazole Zinc Salt; (S)-5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole Zinc Salt
EINECS	Contact for details

Quality Control

Our Esomeprazole Zn is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical intermediates, including identity, purity, and impurity profiles. Certificates of Analysis (COA) are provided and can be tailored to meet specific client requirements, including compliance with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.