Description

2H-1,2-Oxazine-2-Acetic Acid, Tetrahydro-5-Hydroxy--α--Methyl-3-Oxo- is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals, offering a versatile chiral building block for medicinal chemistry research. It is primarily utilized by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new therapeutic agents and high-value compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and anti-inflammatory applications.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Agrochemical Synthesis: Used in the development of advanced, high-efficacy crop protection agents and herbicides.
• Fine Chemical Production: Employed as a building block for synthesizing complex, high-value specialty chemicals and flavors/fragrances.
• Academic & Institutional Research: A valuable reagent for organic synthesis and methodological studies in university and institutional chemistry laboratories.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.

Basic Information

Product Name	2H-1,2-Oxazine-2-Acetic Acid, Tetrahydro-5-Hydroxy--α--Methyl-3-Oxo-
CAS No.	792180-85-9
Molecular Formula	C8H11NO5
Molecular Weight	201.18 g/mol
Synonyms	5-Hydroxy-α-methyl-3-oxotetrahydro-2H-1,2-oxazine-2-acetic acid; Tetrahydro-5-hydroxy-α-methyl-3-oxo-2H-1,2-oxazine-2-acetic acid; 2H-1,2-Oxazine-2-acetic acid, tetrahydro-5-hydroxy-α-methyl-3-oxo-; (5R)-5-Hydroxy-2-methyl-3-oxo-6-oxa-2-azabicyclo[3.2.1]octane-7-carboxylic acid (stereoisomer); LPA 147; A chiral oxazine derivative.
EINECS	Contact for details

Quality Control

Our 2H-1,2-Oxazine-2-Acetic Acid, Tetrahydro-5-Hydroxy--α--Methyl-3-Oxo- is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for all shipments, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.