Description

Masitinib is a potent and selective tyrosine kinase inhibitor targeting c-Kit, PDGFR, and Lyn kinases. This compound is a critical active pharmaceutical ingredient (API) for the research and development of novel therapeutic agents. It is primarily utilized by pharmaceutical companies, biotechnology research institutions, and contract development and manufacturing organizations (CDMOs) engaged in oncology and immunology drug discovery programs.

Application

• Pharmaceutical API: Serves as the core active ingredient in the formulation of investigational new drugs targeting specific kinase pathways.
• Oncology Research: Used in preclinical and clinical research for cancers associated with dysregulated c-Kit and PDGFR signaling, such as gastrointestinal stromal tumors (GIST), mast cell tumors, and certain leukemias.
• Immunology & Inflammatory Disease Research: Investigated for applications in conditions like severe asthma, multiple sclerosis, and rheumatoid arthritis due to its action on mast cells and microglia via Lyn kinase inhibition.
• Biochemical Tool Compound: Employed in laboratory settings as a selective inhibitor to study kinase signaling pathways and cellular mechanisms in disease models.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of masitinib-based drug products.

Basic Information

Product Name	Masitinib
CAS No.	790299-79-5
Molecular Formula	C₂₈H₃₀N₆O
Molecular Weight	466.58 g/mol
Synonyms	AB1010; Masivet; Kinavet; 4-[(4-Methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide; 4-Pyrimidinamine, N-(4-methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)phenyl)-4-((4-methyl-1-piperazinyl)methyl)benzamide
EINECS	Contact for details

Quality Control

Our Masitinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC, to ensure it meets high-grade pharmaceutical standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.