Description

1H-Imidazole-2-Carbonyl Chloride, 4,5-Dihydro- is a versatile and highly reactive chemical intermediate, specifically a dihydroimidazole-based acid chloride. This compound is crucial for introducing the 4,5-dihydroimidazole-2-carbonyl moiety into target molecules, enabling the synthesis of complex heterocyclic systems. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized N-heterocyclic carbene (NHC) ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functional polymers and advanced organic materials with specific electronic or binding properties.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	1H-Imidazole-2-Carbonyl Chloride, 4,5-Dihydro-
CAS No.	782395-53-3
Molecular Formula	C4H5ClN2O
Molecular Weight	132.55 g/mol
Synonyms	4,5-Dihydro-1H-imidazole-2-carbonyl chloride; 2-Imidazoline-2-carbonyl chloride; 2-(Chlorocarbonyl)-4,5-dihydro-1H-imidazole; 4,5-Dihydro-1H-imidazole-2-carboxylic acid chloride; Dihydroimidazole-2-carbonyl chloride; 2-Carboxy-2-imidazoline chloride; 1H-Imidazole-2-carbonyl chloride, 4,5-dihydro-
EINECS	Contact for details

Quality Control

Our production of 1H-Imidazole-2-Carbonyl Chloride, 4,5-Dihydro- adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets exacting standards for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.