Description

3-Piperidinecarbonyl Chloride, 1-Acetyl- (9Ci) is a high-purity, reactive acyl chloride derivative of piperidine, serving as a critical building block in advanced organic synthesis. Its value lies in enabling the efficient introduction of the 1-acetylpiperidine-3-carbonyl moiety, a key structural motif in medicinal chemistry. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and complex molecular scaffolds. The CAS number for this product is 781664-53-7.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, especially in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides requiring specific piperidine-based architectures.
• Peptide Mimetics & PROTACs: Facilitates the construction of peptide-like molecules and Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation.
• Ligand & Catalyst Development: Employed in creating novel ligands for metal complexes and organocatalysts for asymmetric synthesis.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of specialty polymers with unique properties.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules to study biological pathways and protein function.

Basic Information

Product Name	3-Piperidinecarbonyl Chloride, 1-Acetyl- (9Ci)
CAS No.	781664-53-7
Molecular Formula	C8H12ClNO2
Molecular Weight	189.64 g/mol
Synonyms	1-Acetylpiperidine-3-carbonyl chloride; 1-Acetyl-3-piperidinecarbonyl chloride; 3-(Chlorocarbonyl)-1-acetylpiperidine; 1-Acetyl-3-carbamoylpiperidine hydrochloride (precursor related); 3-Carboxy-1-acetylpiperidine chloride; N-Acetyl-3-piperidinecarboxylic acid chloride; Piperidine-3-carbonyl chloride, 1-acetyl derivative
EINECS	Contact for details

Quality Control

Our 3-Piperidinecarbonyl Chloride, 1-Acetyl- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.