Description

Ym155 CAS NO 781661-94-7 is a potent and selective small-molecule survivin inhibitor, a key compound in oncology research and development. Its primary value lies in its ability to suppress survivin expression, a protein overexpressed in many cancer cells that is associated with tumor progression and treatment resistance. This makes it a critical research tool for pharmaceutical companies, academic institutions, and CROs focused on developing novel anti-cancer therapeutics and understanding apoptosis pathways.

Application

• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical studies targeting survivin-dependent cancers.
• Drug Discovery & Development: Serves as a lead compound or pharmacologic tool for validating survivin as a therapeutic target in various cancer cell lines and animal models.
• Apoptosis Mechanism Studies: Employed in biochemical and cellular assays to investigate the regulation of programmed cell death and identify synergistic drug combinations.
• Pharmaceutical Intermediates: Acts as a key synthetic intermediate in the preparation of more complex survivin inhibitor analogs or conjugates.
• Biomedical Research Reagents: Supplied to research laboratories for use in high-throughput screening (HTS) and target validation projects.

Basic Information

Product Name	Ym155
CAS No.	781661-94-7
Molecular Formula	C₂₀H₂₀BrN₃O₃
Molecular Weight	430.30 g/mol
Synonyms	Sepantronium Bromide; YM-155; YM155; 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium Bromide; Survivin Inhibitor YM155; NSC 735367
EINECS	Contact for details

Quality Control

Our Ym155 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with relevant research and development standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.