Description

Denibulin Hydrochloride is a potent and selective small molecule inhibitor with significant therapeutic potential. This high-purity active pharmaceutical ingredient (API) is critical for pharmaceutical research and development, particularly in the field of oncology. It is primarily utilized by pharmaceutical companies and advanced research institutions for the development of novel anti-cancer therapeutics targeting specific cellular pathways.

Application

• Pharmaceutical API Intermediate: Serves as a key building block in the synthesis of finished dosage forms for clinical trials and commercial production.
• Oncology Research: Used in preclinical and clinical research to study its mechanism of action against various cancer cell lines.
• Drug Discovery & Development: Employed in high-throughput screening and lead optimization programs to develop new chemotherapeutic agents.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Biochemical Research: Utilized in studies investigating specific kinase inhibition and related signal transduction pathways.

Basic Information

Product Name	Denibulin Hydrochloride
CAS No.	779356-64-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Denibulin HCl; BAY 43-9006 Tosylate (related compound); Sorafenib intermediate (structural analog); 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methylpyridine-2-carboxamide hydrochloride; Nexavar intermediate; Multikinase inhibitor intermediate
EINECS	Contact for details

Quality Control

Our Denibulin Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting high standards for pharmaceutical research. Certificates of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents are provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.