Description

(1R,2S,4S,5S)-4-[2-Iodo-6-(Methylamino)-9H-Purin-9-Yl]-2-(Phosphonooxy)Bicyclo[3.1.0]Hexane-1-Methanol Dihydrogen Phosphate Ester Tetraammonium Salt is a high-purity, chemically defined nucleotide analog with significant research and pharmaceutical development potential. This compound matters as a key intermediate or active pharmaceutical ingredient (API) precursor in the synthesis of novel therapeutics, particularly in antiviral and anticancer research. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions engaged in nucleoside chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel nucleoside-based antiviral or anticancer drug candidates.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate metabolic pathways and nucleotide processing.
• Proteomics & Molecular Biology: Potential use in the development of probes or tools for studying nucleic acid-protein interactions and cellular signaling.
• Preclinical Development: Serves as a reference standard or starting material for pharmacokinetic, pharmacodynamic, and toxicology studies.
• Antiviral Agent Research: Investigated for its mechanism of action against viral polymerases due to its modified nucleoside structure.
• Labeled Compound Synthesis: Acts as a precursor for introducing iodine or other labels for diagnostic imaging or tracing applications.

Basic Information

Product Name	(1R,2S,4S,5S)-4-[2-Iodo-6-(Methylamino)-9H-Purin-9-Yl]-2-(Phosphonooxy)Bicyclo[3.1.0]Hexane-1-Methanol Dihydrogen Phosphate Ester Tetraammonium Salt
CAS No.	779323-43-2
Molecular Formula	C₁₃H₂₀IN₆O₈P₂ • 4NH₃ (Contact for details)
Molecular Weight	Contact for details
Synonyms	2'-Deoxy-2'-fluoro-2-C-methylguanosine triphosphate analog; 2'-F-2-C-Me-GTP tetraammonium salt; 2-Iodo-6-(methylamino)-9H-purin-9-yl bicyclo[3.1.0]hexane nucleoside triphosphate; 2'-Fluoro-2'-C-methylguanosine-5'-triphosphate, 2-iodo analog; PSI-352938 triphosphate derivative; Anti-HCV nucleoside triphosphate analog; Bicyclo[3.1.0]hexane guanosine triphosphate derivative; Tetraammonium hydrogen phosphate ester of iodinated purine nucleoside
EINECS	Contact for details

Quality Control

Our (1R,2S,4S,5S)-4-[2-Iodo-6-(Methylamino)-9H-Purin-9-Yl]-2-(Phosphonooxy)Bicyclo[3.1.0]Hexane-1-Methanol Dihydrogen Phosphate Ester Tetraammonium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0% (Area %)
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm
Bacterial Endotoxins	<1.0 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.