Description

Benzenesulfonamide, 4-[2-(Trimethylsilyl)Ethynyl]- is a high-value organosilicon building block featuring a sulfonamide core functionalized with a trimethylsilyl-protected acetylene group. This compound is specifically engineered for advanced synthetic chemistry, offering a unique combination of a protected alkyne handle and a versatile sulfonamide moiety. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of complex drug candidates, particularly those targeting enzyme inhibition via sulfonamide pharmacophores.
• Agrochemical Research: Used in the development of new herbicides and fungicides where the sulfonamide group contributes to biological activity.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the creation of specialty polymers and advanced organic frameworks.
• Click Chemistry: The protected alkyne allows for efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to create triazole-linked conjugates.
• Ligand Synthesis: Employed in the preparation of novel ligands for catalysis, leveraging the sulfonamide's coordinating properties.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules, enabling study of biological pathways and interactions.

Basic Information

Product Name	Benzenesulfonamide, 4-[2-(Trimethylsilyl)Ethynyl]-
CAS No.	775331-26-5
Molecular Formula	C11H15NO2SSi
Molecular Weight	253.40 g/mol
Synonyms	4-[(Trimethylsilyl)ethynyl]benzenesulfonamide; N-(4-[(Trimethylsilyl)ethynyl]phenyl)sulfonamide; p-(Trimethylsilylethynyl)benzenesulfonamide; 4-(2-Trimethylsilylethynyl)benzenesulfonamide; TMS-Ethynyl Benzenesulfonamide; 4-Ethynylbenzenesulfonamide TMS ether; (4-Sulfamoylphenyl)ethynyltrimethylsilane
EINECS	Contact for details

Quality Control

Our production of Benzenesulfonamide, 4-[2-(Trimethylsilyl)Ethynyl]- adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized by advanced analytical techniques, and a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided. We support cGMP-compliant manufacturing for advanced projects upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.