Description

(4'-Trifluoromethyl-Biphenyl-2-Yl)-Methanol CAS NO 773871-77-5 is a high-purity fluorinated biphenyl derivative, serving as a critical chiral intermediate in advanced organic synthesis. Its value lies in the unique electronic properties imparted by the trifluoromethyl group, which is essential for modulating the biological activity and physicochemical characteristics of target molecules. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) and inflammatory diseases.
• Ligand and Catalyst Precursor: Used in the development of chiral ligands and organocatalysts for asymmetric synthesis.
• Material Science Research: Serves as a monomer or functional component in the development of specialty polymers and liquid crystals with enhanced thermal and chemical stability.
• Agrochemical Synthesis: Intermediate in the production of advanced herbicides and pesticides, where the CF3 group improves efficacy and environmental profile.
• Chemical Biology Probe: Utilized in the design of molecular probes and inhibitors for studying enzyme function and signal transduction pathways.

Basic Information

Product Name	(4'-Trifluoromethyl-Biphenyl-2-Yl)-Methanol
CAS No.	773871-77-5
Molecular Formula	C14H11F3O
Molecular Weight	252.23 g/mol
Synonyms	[2-(Trifluoromethyl)[1,1'-biphenyl]-4-yl]methanol; (4'-(Trifluoromethyl)-[1,1'-biphenyl]-2-yl)methanol; 2-(Trifluoromethyl)-4'-hydroxymethylbiphenyl; α-(4'-Trifluoromethylbiphenyl-2-yl)methanol; (2'-Hydroxymethyl-5-trifluoromethylbiphenyl); Biphenyl-2-methanol, 4'-trifluoromethyl-; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (4'-Trifluoromethyl-Biphenyl-2-Yl)-Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We can support development and commercial projects requiring compliance with cGMP, ICH guidelines, and other relevant regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorinating agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.