Description

De-1-((2-(2,4-Dichlorophenyl)-1,3-Dioxolan-2-Yl)Methyl)-1H-1,2,4-Triazole Itraconazole Sulfate is a key pharmaceutical intermediate and derivative of the broad-spectrum antifungal agent itraconazole. This compound is critical for research and development in antifungal therapies, offering a pathway to novel formulations and prodrugs. It is primarily required by pharmaceutical manufacturers, research institutions, and fine chemical suppliers engaged in the synthesis of advanced active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of itraconazole and its related antifungal derivatives.
• Antifungal Research: Used in biochemical and pharmacological research to study structure-activity relationships and develop new antifungal agents.
• API Manufacturing: Employed in the production scale-up of itraconazole-based active pharmaceutical ingredients for commercial drug formulations.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Prodrug Development: Investigated for the creation of prodrugs aimed at improving the bioavailability and pharmacokinetic profile of itraconazole.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for specialized chemical entities in the life sciences sector.

Basic Information

Product Name	De-1-((2-(2,4-Dichlorophenyl)-1,3-Dioxolan-2-Yl)Methyl)-1H-1,2,4-Triazole Itraconazole Sulfate
CAS No.	765882-88-0
Molecular Formula	C35H38Cl2N8O4S
Molecular Weight	705.70 g/mol
Synonyms	Itraconazole Sulfate Derivative; De-1-((2-(2,4-Dichlorophenyl)-1,3-Dioxolan-2-yl)methyl)-1H-1,2,4-triazole Itraconazole Sulfate; 1-[(2-(2,4-Dichlorophenyl)-1,3-dioxolan-2-yl)methyl]-1H-1,2,4-triazole Sulfate Salt; Itraconazole Related Compound Sulfate; 4-[4-[4-[4-[[(2R*,4S*)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one Sulfate; Triazole Antifungal Intermediate Sulfate
EINECS	Contact for details

Quality Control

Our De-1-((2-(2,4-Dichlorophenyl)-1,3-Dioxolan-2-Yl)Methyl)-1H-1,2,4-Triazole Itraconazole Sulfate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-grade standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent exposure to atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.