Description

Smac Inhibitor 2 CAS NO 762274-58-8 is a potent and selective small molecule inhibitor of Second Mitochondria-derived Activator of Caspases (Smac) proteins, which are key regulators of apoptosis. This compound is crucial for research into cancer therapeutics, as it disrupts the interaction between Smac and Inhibitor of Apoptosis Proteins (IAPs), thereby promoting programmed cell death in malignant cells. It is an essential research-grade chemical for pharmaceutical R&D, academic institutions, and biotechnology companies focused on oncology, apoptosis signaling pathways, and novel drug discovery.

Application

• Oncology Research: Used as a key pharmacological tool to study apoptosis induction and overcome chemoresistance in various cancer cell lines.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the development of novel Smac mimetics and IAP antagonists.
• Biochemical Assays: Employed in high-throughput screening (HTS) and in vitro assays to evaluate caspase activation and IAP inhibition.
• Signal Pathway Analysis: Critical for investigating the intrinsic apoptosis pathway and the role of Smac/DIABLO in cellular stress responses.
• Preclinical Studies: Utilized in animal models to evaluate the efficacy and pharmacokinetics of pro-apoptotic therapeutic strategies.

Basic Information

Product Name	Smac Inhibitor 2
CAS No.	762274-58-8
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	Smac Inhibitor 2; Smac Mimetic 2; LCL-161 analogue; (S,R)-SM-164; Birinapant analogue; IAP Inhibitor; Apoptosis activator 2; Second mitochondria-derived activator of caspases inhibitor
EINECS	Contact for details

Quality Control

Our Smac Inhibitor 2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and analytical results are provided with every shipment. We adhere to cGMP guidelines for research chemicals to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, freezer environment. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.