Description

Tae226 (Nvp-Tae226) is a potent and selective small molecule inhibitor primarily targeting the FAK (Focal Adhesion Kinase) and IGF-1R (Insulin-like Growth Factor 1 Receptor) signaling pathways. This compound matters for researchers and developers as it serves as a critical pharmacological tool for studying cell adhesion, migration, proliferation, and survival mechanisms in various disease models. It is needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on oncology, fibrosis, and other therapeutic areas where FAK and IGF-1R pathways are implicated. The product is supplied with high purity and batch-to-batch consistency to ensure reliable experimental results.

Application

• Biochemical Research: Used as a selective inhibitor to study the role of FAK and IGF-1R in signal transduction pathways.
• Cancer Research: Investigated in preclinical studies for its potential anti-tumor and anti-metastatic effects in various cancer cell lines and animal models.
• Drug Discovery & Development: Serves as a reference compound or a starting point for the design and synthesis of novel kinase inhibitors.
• Cell Biology Studies: Applied to explore mechanisms of cell adhesion, migration, and invasion in normal and pathological states.
• Fibrosis Research: Utilized in models to understand and potentially intervene in fibrotic diseases where FAK signaling is involved.
• Academic & Institutional Research: A key reagent for fundamental biological research published in scientific literature.

Basic Information

Product Name	Tae226 (Nvp-Tae226)
CAS No.	761437-28-9
Molecular Formula	C₂₃H₂₂N₈O
Molecular Weight	426.47 g/mol
Synonyms	NVP-TAE226; TAE-226; N-(2-(4-((2,4-Diaminopteridin-6-yl)methyl)amino)phenyl)ethyl)-1H-indazole-5-carboxamide; FAK Inhibitor TAE226; IGF-1R/FAK Inhibitor; 1H-Indazole-5-carboxamide, N-[2-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]phenyl]ethyl]-
EINECS	Contact for details

Quality Control

Our Tae226 (Nvp-Tae226) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the product may be stored at 2-8°C. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.