Description

2-Chloro-6-Methoxypurine -9-β-D-(2'-Deoxy-2'-Fluoro)-Arabinoriboside is a high-purity nucleoside analog building block of significant interest in advanced pharmaceutical research and development. This compound is critical for medicinal chemists working on novel antiviral and anticancer therapeutics, particularly in the development of modified nucleosides and nucleotides. Its primary value lies in enabling the synthesis of targeted prodrugs and active pharmaceutical ingredients (APIs) for high-value applications.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of antiviral and anticancer nucleoside analog drugs.
• Antiviral Drug Research: Used in the R&D of novel therapeutics targeting viral polymerases and replication mechanisms.
• Oncology Research: Serves as a building block for creating potential chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Prodrug Synthesis: Essential for constructing targeted prodrug molecules designed for improved bioavailability and selective activation.
• Biochemical Tool Compound: Employed in enzymatic studies and as a probe to investigate nucleoside metabolism and related biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of specialized APIs under cGMP conditions.

Basic Information

Product Name	2-Chloro-6-Methoxypurine -9-β-D-(2'-Deoxy-2'-Fluoro)-Arabinoriboside
CAS No.	758705-70-3
Molecular Formula	C11H12ClFN4O4
Molecular Weight	318.69 g/mol
Synonyms	2-Chloro-6-methoxy-9-[(2-deoxy-2-fluoro-β-D-arabinofuranosyl)]purine; 2-Chloro-6-methoxypurine 2'-deoxy-2'-fluoro-β-D-arabinofuranoside; 2'-Deoxy-2'-fluoro-β-D-arabinofuranosyl-2-chloro-6-methoxypurine; 9-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-2-chloro-6-methoxypurine; 2-Chloro-6-methoxy-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)purine; 2-Cl-6-MeO-Purine 2'-F-ara derivative; Nucleoside analog 758705-70-3
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Methoxypurine -9-β-D-(2'-Deoxy-2'-Fluoro)-Arabinoriboside is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with each shipment. We support development under quality agreements and can supply material aligned with cGMP standards for advanced clinical-stage projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.