Description

Volasertib (BI 6727) is a potent and selective small-molecule inhibitor of Polo-like kinase 1 (Plk1), a key regulator of cell cycle progression. This compound is of significant interest in oncology research for its ability to induce mitotic arrest and apoptosis in rapidly dividing cancer cells. It is primarily utilized by pharmaceutical researchers and development scientists in the fields of anticancer drug discovery, mechanistic studies, and preclinical development.

Application

• Oncology Research & Drug Discovery: As a reference standard and active pharmaceutical ingredient (API) in the development of novel Plk1-targeted cancer therapeutics.
• Biochemical Assays: Used in in vitro enzymatic assays to study Plk1 inhibition kinetics and selectivity profiling.
• Cell-Based Studies: Applied in cell culture experiments to investigate mechanisms of mitotic arrest, apoptosis, and synthetic lethality in various cancer cell lines.
• Preclinical Development: Serves as a critical compound for pharmacokinetic (PK), pharmacodynamic (PD), and toxicology studies in animal models.
• Mechanism of Action (MoA) Research: A vital tool for elucidating the role of Plk1 in tumorigenesis, DNA damage response, and cell cycle checkpoint control.

Basic Information

Product Name	Volasertib (BI 6727)
CAS No.	755038-65-4
Molecular Formula	C₃₀H₄₅N₇O₃
Molecular Weight	539.73 g/mol
Synonyms	BI-6727; BI 6727; Volasertib; (R)-5-(5,7-Dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)-3-((1-(2-(trifluoromethyl)benzyl)piperidin-3-yl)amino)isobenzofuran-1(3H)-one; Polo-like kinase 1 (Plk1) inhibitor BI 6727
EINECS	Contact for details

Quality Control

Our Volasertib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided, ensuring traceability and compliance with research-grade standards. Specifications are designed to meet the rigorous demands of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.