Description

(4-Bromo-2-Fluoro-5-Methoxy-Phenyl)-Methanol is a high-purity fluorinated and brominated benzyl alcohol derivative, serving as a critical building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted biological or physical properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of drug candidates, especially those targeting central nervous system (CNS) disorders, due to its halogenated aromatic structure.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides where the bromo-fluoro-methoxy substitution pattern can influence bioactivity and selectivity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies and organic light-emitting diodes.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination for carbon-carbon and carbon-heteroatom bond formation.
• Ligand & Catalyst Development: The benzylic alcohol group can be functionalized to create chiral or non-chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Polymer Modification: Incorporated as a monomer or modifier to introduce halogenated aromatic units into polymers, altering thermal stability, flame retardancy, or refractive index.

Basic Information

Item	Details
Product Name	(4-Bromo-2-Fluoro-5-Methoxy-Phenyl)-Methanol
CAS No.	749931-19-9
Molecular Formula	C8H8BrFO2
Molecular Weight	235.05 g/mol
Synonyms	4-Bromo-2-fluoro-5-methoxybenzyl alcohol; (4-Bromo-2-fluoro-5-methoxyphenyl)methanol; 2-Fluoro-4-bromo-5-methoxybenzyl alcohol; 5-Methoxy-4-bromo-2-fluorobenzyl alcohol; α-Hydroxymethyl-4-bromo-2-fluoro-5-methoxybenzene; 1-(4-Bromo-2-fluoro-5-methoxyphenyl)methanol
EINECS	Contact for details

Quality Control

Our (4-Bromo-2-Fluoro-5-Methoxy-Phenyl)-Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical characteristics. Our quality commitment aligns with cGMP and ISO 9001 standards where applicable, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.