Description

Luminespib is a potent, selective, and ATP-competitive small-molecule inhibitor of Heat Shock Protein 90 (Hsp90). This compound is a critical research tool and pharmaceutical intermediate for developing novel anti-cancer therapeutics. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on oncology and protein chaperone biology.

Application

• Oncology Research: A key biochemical tool for studying Hsp90's role in cancer cell proliferation, survival, and metastasis.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the development of novel Hsp90-targeted cancer therapies.
• Mechanistic Studies: Used in vitro and in vivo to investigate client protein degradation and the heat shock response pathway.
• Preclinical Evaluation: Employed in pharmacokinetic, pharmacodynamic, and efficacy studies in animal models of cancer.
• Biochemical Assay Development: Acts as a control inhibitor in high-throughput screening (HTS) assays targeting the Hsp90 chaperone machinery.
• Chemical Biology: Useful for probing protein-protein interactions and cellular stress responses dependent on Hsp90 activity.

Basic Information

Product Name	Luminespib
CAS No.	747412-49-3
Molecular Formula	C31H33N5O4
Molecular Weight	539.63 g/mol
Synonyms	NVP-AUY922; AUY-922; VER-52296; 5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-2,4-dihydro-4-(4-morpholinylmethyl)-3H-1,2,4-triazol-3-one; 1,2,4-Triazol-3-one, 5-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-2,4-dihydro-4-[(4-morpholinyl)methyl]-; Hsp90 Inhibitor AUY922
EINECS	Contact for details

Quality Control

Our Luminespib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.