Description

(S)-(-)-1-(4-Bromophenyl)Ethyl Isothiocyanate is a high-purity chiral building block and synthetic intermediate of significant interest in advanced organic synthesis. Its value lies in the combination of a stereogenic center, a reactive isothiocyanate group, and a bromophenyl moiety, enabling precise construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and conducting structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: A key chiral precursor for the synthesis of potential drug candidates, especially in medicinal chemistry programs targeting CNS disorders, oncology, and inflammation.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, where the bromine atom and isothiocyanate group offer sites for further derivatization.
• Ligand and Catalyst Synthesis: Serves as a starting material for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probe Development: The reactive isothiocyanate group allows for selective conjugation with biomolecules (e.g., proteins, peptides) to create probes for studying biological mechanisms.
• Material Science Research: Investigated as a monomer or cross-linking agent for the synthesis of specialized polymers with unique optical or electronic properties.

Basic Information

Product Name	(S)-(-)-1-(4-Bromophenyl)Ethyl Isothiocyanate
CAS No.	745784-02-5
Molecular Formula	C9H8BrNS
Molecular Weight	242.14 g/mol
Synonyms	(S)-1-(4-Bromophenyl)ethyl isothiocyanate; (S)-α-Methyl-4-bromobenzyl isothiocyanate; (-)-1-(4-Bromophenyl)ethyl isothiocyanate; (S)-(-)-1-(p-Bromophenyl)ethyl isothiocyanate; (S)-1-(4-Bromophenyl)ethan-1-yl isothiocyanate; p-Bromo-(S)-α-methylbenzyl isothiocyanate; (S)-1-(4'-Bromophenyl)ethyl isothiocyanate
EINECS	Contact for details

Quality Control

Every batch of (S)-(-)-1-(4-Bromophenyl)Ethyl Isothiocyanate is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing full analytical data including chiral purity (enantiomeric excess), assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.