Description

(R)-(+)-1-(4-Bromophenyl)Ethyl Isothiocyanate CAS NO 745784-01-4 is a high-purity chiral building block and synthetic intermediate characterized by its bromophenyl and isothiocyanate functional groups. This compound is of significant value in asymmetric synthesis and pharmaceutical research, where its defined stereochemistry is critical for creating enantiomerically pure molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the creation of enantiomerically pure pesticides and herbicides, leveraging its bromine handle for further functionalization.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric catalysis.
• Chemical Biology Probes: Utilized in the synthesis of activity-based probes (ABPs) for studying enzyme function and mechanism, exploiting the reactive isothiocyanate group.
• Advanced Material Research: Acts as a monomer or cross-linking agent in the development of specialty polymers with specific optical or electronic properties.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects requiring high stereochemical fidelity and reliable quality.

Basic Information

Product Name	(R)-(+)-1-(4-Bromophenyl)Ethyl Isothiocyanate
CAS No.	745784-01-4
Molecular Formula	C9H8BrNS
Molecular Weight	242.14 g/mol
Synonyms	(R)-1-(4-Bromophenyl)ethyl isothiocyanate; (R)-(+)-1-(p-Bromophenyl)ethyl isothiocyanate; (R)-α-Methyl-4-bromobenzyl isothiocyanate; (+)-(R)-1-(4-Bromophenyl)ethyl isothiocyanate; p-Bromo-(R)-α-methylbenzyl isothiocyanate; (R)-1-(4-Bromophenyl)ethan-1-yl isothiocyanate; (R)-4'-Bromo-α-methylbenzyl isothiocyanate; 1-(4-Bromophenyl)ethyl isothiocyanate, (R)-(+)-
EINECS	Contact for details

Quality Control

Our (R)-(+)-1-(4-Bromophenyl)Ethyl Isothiocyanate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure compliance with high-purity standards for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and chiral purity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.