Description

1-Piperazinecarbonyl Chloride, 4-(1-Methylethyl)- (9Ci) is a specialized organic intermediate featuring a reactive carbonyl chloride group on a substituted piperazine ring. This compound is of significant value in pharmaceutical and advanced chemical synthesis due to its utility as a versatile building block for introducing the 4-isopropylpiperazine-1-carbonyl moiety. It is primarily sought by research and development teams, as well as process chemists, in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the piperazine scaffold can contribute to biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Polymer Modification: Employed to introduce functional piperazine groups into polymer chains, altering properties like solubility, thermal stability, or biocompatibility for advanced materials.
• Chemical Biology Research: Utilized as a probe or linker in proteomics and bioconjugation strategies for studying protein function and interactions.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1-Piperazinecarbonyl Chloride, 4-(1-Methylethyl)- (9Ci)
CAS No.	745731-27-5
Molecular Formula	C8H15ClN2O
Molecular Weight	190.67 g/mol
Synonyms	4-Isopropylpiperazine-1-carbonyl chloride; 1-(Chlorocarbonyl)-4-isopropylpiperazine; 4-Isopropyl-1-piperazinecarbonyl chloride; 4-(Propan-2-yl)piperazine-1-carbonyl chloride; 1-Piperazinecarbonyl chloride, 4-(1-methylethyl)-; 745731-27-5; 4-Isopropyl-piperazine-1-carbonyl chloride
EINECS	Contact for details

Quality Control

Our 1-Piperazinecarbonyl Chloride, 4-(1-Methylethyl)- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and synthesis applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.