Description

Quizartinib is a potent and highly selective small-molecule inhibitor of FMS-like tyrosine kinase 3 (FLT3), specifically targeting the FLT3-ITD mutation. This compound is of critical importance in the field of targeted cancer therapy, offering a promising mechanism of action for the treatment of relapsed or refractory acute myeloid leukemia (AML). Pharmaceutical manufacturers, research institutions, and biotechnology companies engaged in oncology drug development require this high-purity active pharmaceutical ingredient (API) for clinical research and formulation.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in the formulation of targeted cancer therapeutics.
• Key component in preclinical and clinical research for acute myeloid leukemia (AML), particularly studies focusing on FLT3-ITD mutated cancers.
• Reference standard for analytical method development and validation (e.g., HPLC, LC-MS) in quality control laboratories.
• Biochemical tool for in vitro pharmacological studies investigating FLT3 signaling pathways and inhibitor mechanisms.
• Starting material or intermediate for the synthesis of novel derivatives in medicinal chemistry programs.
• Used in combination therapy research to explore synergistic effects with other anticancer agents.

Basic Information

Product Name	Quizartinib
CAS No.	743438-45-1
Molecular Formula	C29H32N6O3
Molecular Weight	512.60 g/mol
Synonyms	AC220; Quizartinib dihydrochloride (salt form); 6-(5-tert-Butyl-isoxazol-3-ylamino)-7-fluoro-3-methyl-2-[(2R)-1-(2-morpholin-4-ylethyl)pyrrolidin-2-yl]methoxy-3H-quinazolin-4-one; UNII-4BZ6K6L8PJ; FLT3 Inhibitor AC220
EINECS	Contact for details

Quality Control

Our Quizartinib is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical research and development. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling, to ensure compliance with in-house specifications aligned with ICH guidelines. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.