Description

Isavuconazonium Sulfate is a water-soluble prodrug of the active triazole antifungal agent isavuconazole. This compound is critically important as the active pharmaceutical ingredient (API) in commercial antifungal medications used to treat serious systemic fungal infections. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of advanced antifungal therapies. Its specific mechanism and high efficacy make it a key component in modern anti-infective drug portfolios.

Application

• Pharmaceutical Active Ingredient (API): As the core component in finished dosage forms for the treatment of invasive aspergillosis and mucormycosis.
• Antifungal Drug Formulation: Used in the research, development, and commercial manufacturing of intravenous (IV) and oral antifungal medications.
• Clinical Research: Serves as a reference standard and key material in preclinical and clinical studies for new antifungal agents or combination therapies.
• Pharmacology Studies: Utilized in laboratory investigations to study the pharmacokinetics, metabolism, and mechanism of action of triazole antifungals.
• GMP Manufacturing: Supplied to contract manufacturing organizations (CMOs) and innovator companies for cGMP-compliant drug production.
• Quality Control Reference: Acts as a high-purity standard for analytical testing and method validation in pharmaceutical quality control laboratories.

Basic Information

Product Name	Isavuconazonium Sulfate
CAS No.	742049-41-8
Molecular Formula	C35H35F2N8O5S
Molecular Weight	717.76 g/mol
Synonyms	Isavuconazonium sulfate; BAL8557; (2R,3R)-2-(2,5-Difluorophenyl)-3-(5-fluoro-4-{4-[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)pyridin-2-yl]piperazin-1-yl}pyridin-2-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl dimethylcarbamate sulfate; Cresemba (brand name) API; Isavuconazole prodrug sulfate
EINECS	Contact for details

Quality Control

Our Isavuconazonium Sulfate is manufactured and tested under a strict quality management system. Each batch is analyzed to meet high-purity standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) is provided, detailing results for identity, purity, assay, and specified impurities. We support compliance with ICH guidelines and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Related Substances (HPLC)	Individual impurity: ≤0.5%; Total impurities: ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.