Description

(S)-(+)-1-Cyclohexylethyl Isothiocyanate is a high-purity chiral building block and reagent of significant interest in advanced organic synthesis. Its value lies in the unique reactivity of the isothiocyanate group and the defined stereochemistry of the cyclohexylethyl moiety, enabling the construction of complex, optically active molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients, chiral ligands, and specialty fine chemicals where precise stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential drug candidates, especially in medicinal chemistry programs targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Research: Used in the development of novel, stereospecific pesticides and herbicides, where the (S)-configuration can influence biological activity and environmental degradation profiles.
• Chiral Ligand & Catalyst Preparation: Serves as a precursor for synthesizing novel thiourea-based chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics & Bioconjugation: The isothiocyanate group is highly reactive towards amines, making it valuable for creating peptide analogs (peptidomimetics) and for bioconjugation applications in chemical biology.
• Material Science: Employed as a monomer or cross-linking agent in the research of specialty polymers with tailored thermal and mechanical properties.
• Analytical Chemistry: Can be used as a derivatization agent for chiral separation techniques or as a standard for method development and validation.

Basic Information

Product Name	(S)-(+)-1-Cyclohexylethyl Isothiocyanate
CAS No.	737000-92-9
Molecular Formula	C9H15NS
Molecular Weight	169.29 g/mol
Synonyms	(S)-1-Cyclohexylethyl isothiocyanate; (S)-(+)-1-(Cyclohexyl)ethyl isothiocyanate; (1S)-1-Cyclohexylethyl isothiocyanate; (+)-(S)-1-Cyclohexylethyl isothiocyanate; (S)-α-Methylcyclohexanemethyl isothiocyanate; (S)-1-Isothiocyanato-1-cyclohexylethane; (S)-1-Cyclohexyl-1-isothiocyanatoethane
EINECS	Contact for details

Quality Control

Our (S)-(+)-1-Cyclohexylethyl Isothiocyanate is manufactured under strict quality control protocols to ensure high chemical and optical purity, critical for sensitive synthetic applications. Each batch is analyzed using advanced chromatographic and spectroscopic techniques, including HPLC, GC, and polarimetry. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (Karl Fischer)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.