Description

(R)-(-)-1-(4-Fluorophenyl)Ethyl Isothiocyanate is a high-purity chiral building block and key intermediate in advanced organic synthesis. This compound matters for its role in constructing complex molecules with defined stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs) and agrochemicals with specific biological activity. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for applications in medicinal chemistry, process development, and asymmetric synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of enantiomerically pure pesticides and herbicides for enhanced efficacy and environmental safety.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric transformations.
• Chemical Biology Research: Employed in the design and synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Material Science: Potential monomer for creating specialized polymers with unique optical or electronic properties.

Basic Information

Product Name	(R)-(-)-1-(4-Fluorophenyl)Ethyl Isothiocyanate
CAS No.	737000-82-7
Molecular Formula	C9H8FNS
Molecular Weight	181.23 g/mol
Synonyms	(R)-1-(4-Fluorophenyl)ethyl isothiocyanate; (R)-α-Methyl-4-fluorobenzyl isothiocyanate; (R)-(-)-1-(p-Fluorophenyl)ethyl isothiocyanate; (R)-1-(4-Fluorophenyl)ethan-1-yl isothiocyanate; (R)-FEITC; (R)-4-Fluorophenethyl isothiocyanate isomer; (R)-1-(4'-Fluorophenyl)ethyl isothiocyanate
EINECS	Contact for details

Quality Control

Our production of (R)-(-)-1-(4-Fluorophenyl)Ethyl Isothiocyanate adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques, including chiral HPLC, to confirm identity and purity. Certificates of Analysis (COA) detailing specific results for chiral purity, chemical purity, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.